Implications of miR cluster 143/145 as universal anti-oncomiRs and their dysregulation during tumorigenesis
نویسندگان
چکیده
منابع مشابه
MicroRNAs and their therapeutic potential for human diseases: microRNAs, miR-143 and -145, function as anti-oncomirs and the application of chemically modified miR-143 as an anti-cancer drug.
We examined the expression levels of microRNAs (miRNAs; miRs) in colorectal tumors (63 cancer specimens and 65 adenoma specimens) compared to adjacent non-tumorous tissues. Decreased expression of miR-143 and -145 was frequently observed in the adenoma and cancer samples. As the down-regulation of miR-143 and -145 was observed even in the early phase of adenoma formation, their decreased expres...
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ژورنال
عنوان ژورنال: Cancer Cell International
سال: 2015
ISSN: 1475-2867
DOI: 10.1186/s12935-015-0247-4